Diseases
2
associated indications
Drugs
0
with a known mechanism
Trials
0
via those drugs
Companies
0
on linked trials
Structure
AlphaFold model for P43246 · mean pLDDT 85.3
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Identity
Synonyms, protein accessions, and subcellular locations
Synonyms
COCA1
DNA mismatch repair protein Msh2
DNA mismatch repair protein Msh2 transcript
FCC1
HNPCC
HNPCC1
LCFS2
LYNCH1
MMRCS2
MSH-2
MSH2
MutS protein homolog 2
MutS-like 2
hMSH2
mutS homolog 2, colon cancer, nonpolyposis type 1
Protein IDs
ensembl_PRO
ENSP00000233146
ensembl_PRO
ENSP00000384199
ensembl_PRO
ENSP00000442697
ensembl_PRO
ENSP00000495455
ensembl_PRO
ENSP00000495543
ensembl_PRO
ENSP00000495641
ensembl_PRO
ENSP00000496351
ensembl_PRO
ENSP00000496441
ensembl_PRO
ENSP00000519159
ensembl_PRO
ENSP00000519165
ensembl_PRO
ENSP00000519166
ensembl_PRO
ENSP00000519172
ensembl_PRO
ENSP00000519219
ensembl_PRO
ENSP00000580467
ensembl_PRO
ENSP00000580468
ensembl_PRO
ENSP00000588159
ensembl_PRO
ENSP00000588160
ensembl_PRO
ENSP00000588161
ensembl_PRO
ENSP00000588162
ensembl_PRO
ENSP00000588163
ensembl_PRO
ENSP00000588164
ensembl_PRO
ENSP00000588165
ensembl_PRO
ENSP00000588166
ensembl_PRO
ENSP00000588167
ensembl_PRO
ENSP00000616875
uniprot_obsolete
B4E2Z2
uniprot_obsolete
O75488
uniprot_swissprot
P43246
uniprot_trembl
A0A2R8Y6P0
uniprot_trembl
A0A2R8Y713
uniprot_trembl
A0A2R8Y7S8
uniprot_trembl
A0A2R8YFH0
uniprot_trembl
A0A2R8YG02
uniprot_trembl
A0AAQ5BH31
uniprot_trembl
A0AAQ5BH33
uniprot_trembl
A0AAQ5BH41
uniprot_trembl
A0AAQ5BH48
uniprot_trembl
A0AAQ5BH55
uniprot_trembl
E9PHA6
Subcellular location
Cellular component
Nucleoplasm
Pipeline by phase
Trial momentum
Associated diseases
2 indications loaded
| Disease | Score | Best evidence | Drugged here? |
|---|---|---|---|
|
ovarian cancer
MONDO_0008170
|
0.74
|
Genetic literature | No |
|
non-small cell lung carcinoma
MONDO_0005233
|
0.43
|
Literature | No |
Evidence mix
What the association scores rest on
| Evidence type | Associations | Best score |
|---|---|---|
| Literature | 2 | 0.721 |
| Somatic mutation | 2 | 0.767 |
| Genetic association | 1 | 0.861 |
| Genetic literature | 1 | 0.865 |
| RNA expression | 1 | 0.104 |
Literature concepts
What papers discuss for this target
Mechanism of action
Cytotoxic
158
Inhibitor
134
Immune checkpoint blockade
83
Kinase inhibition
14
Immunomodulation
5
Modality
Small molecule
12
Oligonucleotide
11
Antibody
9
Cell therapy
5
CAR-T
4
Payload
Topoisomerase I inhibitor
18
DXd
16
Maytansinoid
14
DM1
11
SN-38
6
Linker
Cleavable
21
GGFG tetrapeptide
16
Non-cleavable
11
SMCC
11
mc-vc-PAB
7
Technology
CRISPR
7
Single-cell sequencing
2
Therapy area
Oncology
743
Pathological conditions
317
Urology / nephrology
270
Endocrinology
244
Gastroenterology / hepatology
200
Baseline expression
Highest nTPM by tissue, cell type, and cell line
Tissue
| Tissue | nTPM |
|---|---|
| retina | 32.4 |
| thymus | 30.4 |
| tonsil | 23.4 |
| lymph node | 22.3 |
| testis | 15.2 |
| bone marrow | 15.0 |
| thyroid gland | 15.0 |
| breast | 14.8 |
| rectum | 14.1 |
| parathyroid gland | 13.9 |
| cerebral cortex | 13.3 |
| cerebellum | 13.3 |
Cell type
| Cell type | nTPM |
|---|---|
| cone photoreceptor cells | 294.0 |
| rod photoreceptor cells | 158.9 |
| erythrocyte progenitors | 145.5 |
| early primary spermatocytes | 117.5 |
| brain inhibitory neurons | 113.6 |
| distal convoluted tubule cells | 109.4 |
| brain excitatory neurons | 97.1 |
| differentiating spermatogonia | 94.9 |
| megakaryocyte-erythroid progenitors | 87.4 |
| renal connecting tubule cells | 84.3 |
| pituitary stem cells | 83.2 |
| retinal bipolar cells | 83.0 |
Cell line
| Cell line | nTPM |
|---|---|
| TK [Human B-cell lymphoma] | 211.6 |
| MFM-223 | 163.0 |
| JM-1 | 146.6 |
| NTERA-2 | 146.1 |
| BL-70 | 127.7 |
| U-698-M | 127.4 |
| DMS 79 | 127.3 |
| Farage | 122.8 |
| NCI-H187 | 121.4 |
| SU-DHL-8 | 119.7 |
| EB3 [Human Burkitt lymphoma] | 118.2 |
| SU-DHL-5 | 118.1 |