Targets
Cross-disease gene catalog with opportunity filters
1-25 of 15731
Genes
15731
with an association
Associations
23814
scored disease-gene pairs
Strong undrugged
110
best link ≥ 0.5, no drug mechanism
With a drug
664
any known mechanism target
Opportunity mix
Most connected genes
All targets
Cross-disease gene catalog with opportunity filters
| Gene | Diseases | Association score desc | Drugged? |
|---|---|---|---|
|
EGFR
epidermal growth factor receptor
|
2 |
0.89
|
Yes |
|
BRCA1
BRCA1 DNA repair associated
|
2 |
0.88
|
No |
|
BRCA2
BRCA2 DNA repair associated
|
2 |
0.88
|
No |
|
KRAS
KRas proto-oncogene, GTPase
|
2 |
0.83
|
Yes |
|
RAD51C
RAD51 paralog C
|
2 |
0.83
|
No |
|
ALK
ALK receptor tyrosine kinase
|
2 |
0.81
|
Yes |
|
ERBB2
erb-b2 receptor tyrosine kinase 2
|
2 |
0.81
|
Yes |
|
TP53
tumor protein p53
|
2 |
0.81
|
Yes |
|
ROS1
ROS proto-oncogene 1, receptor tyrosine kinase
|
2 |
0.81
|
Yes |
|
MET
MET proto-oncogene, receptor tyrosine kinase
|
2 |
0.81
|
Yes |
|
RAD51D
RAD51 paralog D
|
2 |
0.80
|
No |
|
DICER1
dicer 1, ribonuclease III
|
2 |
0.79
|
No |
|
BRIP1
BRCA1 interacting DNA helicase 1
|
2 |
0.79
|
No |
|
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase cata…
|
2 |
0.79
|
Yes |
|
RET
ret proto-oncogene
|
2 |
0.78
|
Yes |
|
PALB2
partner and localizer of BRCA2
|
2 |
0.77
|
No |
|
BRAF
B-Raf proto-oncogene, serine/threonine kinase
|
2 |
0.76
|
Yes |
|
PTEN
phosphatase and tensin homolog
|
2 |
0.76
|
No |
|
MSH6
mutS homolog 6
|
2 |
0.76
|
No |
|
ERBB4
erb-b2 receptor tyrosine kinase 4
|
2 |
0.76
|
Yes |
|
EML4
EMAP like 4
|
2 |
0.75
|
Yes |
|
POLE
DNA polymerase epsilon, catalytic subunit
|
2 |
0.75
|
Yes |
|
STK11
serine/threonine kinase 11
|
2 |
0.74
|
No |
|
MSH2
mutS homolog 2
|
2 |
0.74
|
No |
|
CHEK2
checkpoint kinase 2
|
2 |
0.73
|
Yes |